LUPAS (242098)

  https://cordis.europa.eu/project/id/242098

  FP7 (2007-2013)

  Luminescent polymers for in vivo imaging of amyloid signatures

  Activatable or smart in vivo imaging agents reporting on physico-chemical or molecular changes relevant to the diagnosis and/or monitoring of diseases (HEALTH-2009-1.2-5)

  alzheimer  ·  polymer sciences  ·  optics  ·  magnetic resonance imaging  ·  nano-materials

  2009-11-01 Start Date (YY-MM-DD)

  2012-12-31 End Date (YY-MM-DD)

  € 6,475,643 Total Cost

  Description

In this project we seek to develop new smart imaging molecular tools for combating neurodegenerative diseases such as Alzheimer’s disease and prion diseases. Emphasis is put on translational applied research for the development and validation of novel properly functionalized luminescent conjugated polymers (LCP) that via modern imaging technology can give rise to entirely new and innovative methodology for studying neurodegenerative diseases. The objectives include the development of novel imaging agents that can be utilized for biomedical research, diagnosis, monitoring and prognosis, and for support and guidance of therapeutic interventions for Alzheimer’s disease and prion diseases. The consortium is composed of expert groups in experimental optics, polymer synthesis, magnetic resonance imaging (MRI), synthesis of functionalized magnetic nanoparticles, amyloid structure, AD mouse models, clinical AD, and prion diseases. At the same time this project establishes strategic links between mainly SME based Industries, expert researchers at universities and principal users in terms of hospitals. The project consortium will develop and share an efficient plan for dissemination and exploitation of the project results.

  Complicit Organisations

1 Israeli organisation participates in LUPAS.