PROADS (268226)

  https://cordis.europa.eu/project/id/268226

  FP7 (2007-2013)

  Molecular Recognition: Understanding Proteins Adsorption to Inorganic Surfaces

  Marie Curie Action: "Reintegration Grants" (FP7-PEOPLE-2009-RG)

  composites  ·  proteins  ·  amines  ·  implants  ·  spectroscopy

  2010-09-01 Start Date (YY-MM-DD)

  2014-08-31 End Date (YY-MM-DD)

  € 100,000 Total Cost

  Description

Understanding how proteins adsorb to inorganic surfaces is important in many biotechnological applications, including the design of medical implants, fabrication of antibacterial surfaces and biomeneralization. Many studies have been carried out in order to examine how proteins interact with inorganic entities or surfaces; still, it is not clear how proteins “sense” the inorganic surface. The aim of the proposed research is get insights into the fundamental rules that govern protein adsorption. The approach will combine the use of two powerful tools: atomic force spectroscopy and self-assembled monolayers. It will undertake a reductionist methodology and study the adsorption of individual amino acids to chemically well-defined surfaces, functionalized with self-assembled monolayers, using single-molecule spectroscopy. The experimental approach that will be developed, in the course of the project, will be useful as a tool for other researches in the field. Additionally, findings from this research will allow the design of antibacterial surfaces, new biomaterials and peptides that interact with inorganic surfaces or particles in a controlled manner to form composite materials.

  Complicit Organisations

1 Israeli organisation participates in PROADS.