TIGITtherapy (721317)

  https://cordis.europa.eu/project/id/721317

  Horizon 2020 (2014-2020)

  TIGIT therapy for cancer treatment

  ERC-Proof of Concept-2016 (ERC-PoC-2016)

  oncology  ·  immunotherapy

  2017-07-01 Start Date (YY-MM-DD)

  2018-12-31 End Date (YY-MM-DD)

  € 150,000 Total Cost

  Description

Treating tumors with immune-related therapies is one of the most exciting and promising advancements made in the past decade. Cancer immunotherapy drugs have captured nearly 50% of the overall oncology drugs market. TIGIT is an important checkpoint inhibitory receptor discovered by our group in 2009. It is constitutively expressed by various immune cells and its expression is further increased on tumor infiltrating lymphocytes (TILs). TIGIT recognizes two main ligands, PVR and Nectin2 that are highly expressed on various tumors. Blockage of TIGIT on TILs either alone or in combination with another checkpoint inhibitory receptor, PD-1, leads to increased T and Natural Killer (NK) cell activity in vitro and inhibited tumor growth in vivo. We developed 9 different anti-TIGIT mAbs during my BacNK ERC advanced grant and previously. In the POC grant TIGITtherapy, which already attracted interest from several bio pharma companies, I propose testing which of the 9 anti-TIGIT mAbs and TIGIT-Ig are able to antagonize TIGIT activity.

  Complicit Organisations

1 Israeli organisation participates in TIGITtherapy.