IMMEDIATE (101095540)
https://cordis.europa.eu/project/id/101095540
Horizon Europe (2021-2027)
Imminent Disease Prediction and Prevention at the Environment Host Interface
Personalised blueprint of chronic inflammation in health-to-disease transition (HORIZON-HLTH-2022-STAYHLTH-02-01)
nutrition · sensors
2023-01-01 Start Date (YY-MM-DD)
2026-12-31 End Date (YY-MM-DD)
€ 6,221,606 Total Cost
Description
IMMEDIATE aims to investigate and explore the diet-microbiome-immunometabolism-axis as a sensor for health-to-disease transition and evaluate strategies to maintain an individuals well-being. Chronic inflammation is the major root of most diseases. Understanding of this process preceding organ dysfunction or damage and identification of biomarkers in the pre-symptomatic stage and risk but also resilience factors of health-to-disease transition will enable targeted and personalized interventions to prevent irreversible organ damage. Metabolites of gut microbiota are key messengers between diet, microbiota and host, maintaining the balance of pro- and anti-inflammation. Our study takes advantage of cutting-edge omics technologies available within the IMMEDIATE consortium in conjunction with available clinical data and biospecimens from ongoing observational studies, enrolling healthy subjects and individuals in the pre-disease stage but with largely distinct environmental and dietary modulators, including a cohort of kidney transplant recipients in whom renal function has been reset to baseline. The identification of clinical and omics-derived biomarkers will by employing AI algorithms - yield a personalized risk / resilience score of chronic inflammation and thus a better prediction of an individuals risk of transition towards disease. A proof-of-concept intervention study with the anti-inflammatory microbe Akkermansia muciniphila will be conducted to test whether deflections of the microbiome-metabolite-immune axis can be reverted on the biomarker level but also with respect to clinical outcomes and overall well-being. Mobile apps developed by the IMMEDIATE consortium in collaboration with patient organizations tracking numerous lifestyle-related measures and providing guidance and feedback on these aspects will empower individuals to adopt and integrate these knowledge-based health interventions into their own lives, hereby self-managing their own health.