OVAL (190124455)

  https://cordis.europa.eu/project/id/190124455

  Horizon Europe (2021-2027)

  The OVAL study for VB-111 treatment of platinum-resistant ovarian cancer

  EIC Accelerator Open 2021 (HORIZON-EIC-2021-ACCELERATOROPEN-01)

  gene therapy  ·  immunology  ·  oncology

  2022-04-01 Start Date (YY-MM-DD)

  2024-03-31 End Date (YY-MM-DD)

  € 7,037,500

  Description

VBL therapeutics is a late-stage clinical biopharmaceutical company focused on first in class treatments for cancer. VBL's lead oncology product candidate, VB-111, is an innovative targeted anti-cancer gene therapy with potential to treat a wide range of solid tumors. Most cancer therapies aim to target tumors cells while sparing normal cells, but tumors are heterogeneous and often develop resistance to treatment. Instead of targeting the tumor directly, VB-111 targets the tumor environment by disrupting the blood vessels that supply blood to the tumor and by recruiting the immune system into the tumor. This dual mechanism of action together with an excellent safety profile make VB-111 a game-changer. VBL is pursuing Ovarian Cancer as the first indication for VB-111. In the scope of this project, VBL will to finalize a Phase 3 potential-registration clinical trial, the OVAL study as well as execute all the necessary steps towards final regulatory approvals and commercialization

  Complicit Organisations

1 Israeli organisation participates in OVAL.